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Anti-GFM1 Antibody (CAB5077)

SKU:
CAB5077
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
GFM1
COXPD1
EFG
EFG1
EFGM
EGF1
GFM
hEFG1
Research Area:
Metabolism
  • Metabolism Antibodies 2 Anti-GFM1 Antibody CAB5077
  • Metabolism Antibodies 2 Anti-GFM1 Antibody CAB5077
  • Metabolism Antibodies 2 Anti-GFM1 Antibody CAB5077
  • Metabolism Antibodies 2 Anti-GFM1 Antibody CAB5077
  • Metabolism Antibodies 2 Anti-GFM1 Antibody CAB5077
€139 - €419
Frequently bought together:

Description

Product Name:GFM1 Rabbit pAb
Product Code:CAB5077
Size:20uL, 50uL, 100uL
Synonyms:GFM1, COXPD1, EFG, EFG1, EFGM, EGF1, GFM, hEFG1
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 482-751 of human GFM1 (NP_079272.4).
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 482-751 of human GFM1 (NP_079272.4).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VYFD TENK ETVI SGMG ELHL EIYA QRLE REYG CPCI TGKP KVAF RETI TAPV PFDF THKK QSGG AGQY GKVI GVLE PLDP EDYT KLEF SDET FGSN IPKQ FVPA VEKG FLDA CEKG PLSG HKLS GLRF VLQD GAHH MVDS NEIS FIRA GEGA LKQA LANA TLCI LEPI MAVE VVAP NEFQ GQVI AGIN RRHG VITG QDGV EDYF TLYA DVPL NDMF GYST ELRS CTEG KGEY TMEY SRYQ PCLP STQE DVIN KYLE ATGQ LPVK KGKA KN
Gene ID:85476
Uniprot:Q96RP9
Cellular Location:Mitochondrion
Calculated MW:83kDa/85kDa
Observed MW:Refer to figures
UniProt Protein Function:EFG1: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Defects in GFM1 are the cause of combined oxidative phosphorylation deficiency type 1 (COXPD1). It leads to early fatal progressive hepatoencephalopathy. Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Translation elongation; Mitochondrial; RNA-binding

Chromosomal Location of Human Ortholog: 3q25

Cellular Component: mitochondrial matrix

Molecular Function:GTPase activity; protein binding; GTP binding; translation elongation factor activity

Biological Process: mitochondrial translation; organelle organization and biogenesis

Disease: Combined Oxidative Phosphorylation Deficiency 1

NCBI Summary:Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. [provided by RefSeq, Jul 2008]
UniProt Code:Q96RP9
NCBI GenInfo Identifier:116241346
NCBI Gene ID:85476
NCBI Accession:Q96RP9.2
UniProt Related Accession:Q96RP9
Molecular Weight:
NCBI Full Name:Elongation factor G, mitochondrial
NCBI Synonym Full Names:G elongation factor mitochondrial 1
NCBI Official Symbol:GFM1  
NCBI Official Synonym Symbols:EFG; GFM; EFG1; EFGM; EGF1; hEFG1; COXPD1; mtEF-G1  
NCBI Protein Information:elongation factor G, mitochondrial
UniProt Protein Name:Elongation factor G, mitochondrial
UniProt Synonym Protein Names:Elongation factor G 1, mitochondrial; Elongation factor G1
UniProt Gene Name:GFM1  
UniProt Entry Name:EFGM_HUMAN

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