The GFER Polyclonal Antibody (PAC049210) is a valuable tool for researchers studying the GFER protein, which plays a crucial role in mitochondrial function and oxidative stress response. This antibody, produced in rabbits, is highly specific for detecting GFER in human samples and has been validated for use in Western blot applications. By targeting the GFER protein, researchers can gain insights into its function in various cellular processes, making it an essential tool for studies in mitochondrial biology and aging research.
GFER, also known as Growth Factor, Augmenter of Liver Regeneration, is a key player in maintaining mitochondrial homeostasis and protecting cells from oxidative damage. Dysregulation of GFER has been linked to various diseases, including neurodegenerative disorders and metabolic conditions. By understanding the role of GFER in cellular physiology, researchers can uncover potential therapeutic targets for these diseases and develop strategies to enhance mitochondrial function and combat oxidative stress.
Antibody Name:
Gfer Antibody (PACO49210)
Antibody SKU:
PACO49210
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Rat
Immunogen:
Recombinant Rat FAD-linked sulfhydryl oxidase ALR protein (1-198AA)
FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. May have a function in liver regeneration and spermatogenesis.
Function: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. May have a function in liver regeneration and spermatogenesis.1 PublicationManual assertion based on experiment in:Ref.1Catalytic activity: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.Cofactor: FAD.1 PublicationManual assertion based on experiment in:Ref.3
UniProt Protein Details:
NCBI Summary:
protein that augments liver regeneration [RGD, Feb 2006]
