The GFAP Polyclonal Antibody (CAB14673) is a valuable tool for researchers studying glial fibrillary acidic protein (GFAP), a key protein found in astrocytes in the central nervous system. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in immunofluorescence and immunohistochemistry applications. By binding specifically to GFAP, this antibody allows for the visualization and analysis of GFAP expression in various cell types and tissues, making it an essential component in neuroscience and neurology research.GFAP is a marker for astrocytes, the most abundant cell type in the brain, and is involved in providing structural support and maintaining the integrity of the blood-brain barrier.
Changes in GFAP expression have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Therefore, studying the expression and localization of GFAP using this antibody can provide valuable insights into the pathogenesis of these conditions and potentially lead to the development of novel diagnostic and therapeutic strategies.
Product Name:
GFAP Rabbit Polyclonal Antibody
SKU:
CAB14673
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-432 of human GFAP (NP_002046.1).
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
2670
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using GFAP Rabbit pAb (CAB14673) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
