The GFAP Polyclonal Antibody (CAB0237) is a vital tool for researchers studying glial fibrillary acidic protein (GFAP), a key marker for astrocytes in the central nervous system. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been rigorously validated for use in techniques such as Western blotting.GFAP is crucial for maintaining the structural integrity and function of astrocytes, which are essential for supporting neuronal health and function in the brain and spinal cord. Abnormal levels or expression patterns of GFAP have been linked to various neurological disorders, including Alzheimer's disease, traumatic brain injury, and multiple sclerosis.
By using the GFAP Polyclonal Antibody, researchers can accurately detect and quantify GFAP levels in different experimental settings, providing valuable insights into the role of astrocytes in neurodegenerative diseases, brain injury, and other neurological conditions. This antibody is a valuable tool for advancing our understanding of astrocyte function and potential therapeutic targets in the field of neuroscience research.
Product Name:
GFAP Rabbit Polyclonal Antibody
SKU:
CAB0237
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-75 of human GFAP (NP_002046.1).
Sequence:
MERR RITS AARR SYVS SGEM MVGG LAPG RRLG PGTR LSLA RMPP PLPT RVDF SLAG ALNA GFKE TRAS ERAE MME
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
2670
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using GFAP Rabbit pAb (CAB0237) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
