The Gephyrin Rabbit Monoclonal Antibody (CAB4729) is a cutting-edge tool for researchers studying the protein gephyrin, a key player in the regulation of inhibitory neurotransmission in the brain. This antibody, generated from rabbit hosts, is highly specific to human samples and has been extensively validated for use in Western blot applications. By binding to gephyrin, this antibody enables precise detection and analysis of this crucial protein in various cell types, making it an essential tool for neuroscience and neurology research. Gephyrin is a scaffolding protein that plays a vital role in the clustering and anchoring of inhibitory neurotransmitter receptors at synapses in the central nervous system. Dysregulation of gephyrin has been implicated in various neurological disorders, including epilepsy, autism, and schizophrenia.
By understanding the function and localization of gephyrin, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially develop novel therapies to target them. The Gephyrin Rabbit Monoclonal Antibody (CAB4729) offers researchers a highly specific and reliable tool for investigating the role of gephyrin in neurobiology and neurological disorders. Its high reactivity, specificity, and validated performance make it an essential reagent for studies aiming to elucidate the molecular mechanisms of inhibitory neurotransmission and their relevance to neurological health and disease.
Product Name:
Gephyrin Rabbit Monoclonal Antibody
SKU:
CAB4729
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Gephyrin (NP_001019389).
This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known.
Purification Method:
Affinity purification
Gene ID:
10243
Clone Number:
ARC1109
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Gephyrin Rabbit mAb (CAB4729) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
