The Genome Polyprotein Antibody (PACO36338) is a valuable tool for researchers studying the genome polyprotein, a key player in viral replication and infection. This polyclonal antibody, generated from high-quality sources, is specifically designed for use in immunofluorescence and ELISA applications. It is highly sensitive and specific, making it ideal for detecting and studying the expression of the genome polyprotein in various experimental settings.The genome polyprotein is a critical component of viral life cycles, serving as a precursor that is processed into functional proteins essential for viral replication and assembly.
By targeting the genome polyprotein, researchers can gain insights into the mechanisms behind viral pathogenesis and potentially identify new targets for antiviral therapies.In addition to its role in virology research, the genome polyprotein antibody can also be utilized in the study of host-virus interactions, viral evolution, and vaccine development. Its versatility and reliability make it a valuable asset for scientists working in the fields of virology, molecular biology, and infectious diseases. Unlock the potential of your research with the Genome Polyprotein Antibody (PACO36338).
Antibody Name:
Genome polyprotein Antibody (PACO36338)
Antibody SKU:
PACO36338
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human enterovirus 71
Immunogen:
Recombinant Human enterovirus 71 Genome polyprotein protein (566-862AA)
Capsid protein VP1: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor to provide virion attachment to target host cells. This attachment induces virion internalization. Tyrosine kinases are probably involved in the entry process. After binding to its receptor, the capsid undergoes conformational changes. Capsid protein VP1 N-terminus (that contains an amphipathic alpha-helix) and capsid protein VP4 are externalized. Together, they shape a pore in the host membrane through which viral genome is translocated to host cell cytoplasm. After genome has been released, the channel shrinks.
Synonyms:
Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
UniProt Protein Function:
Capsid protein VP1: Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor to provide virion attachment to target host cells. This attachment induces virion internalization. Tyrosine kinases are probably involved in the entry process. After binding to its receptor, the capsid undergoes conformational changes. Capsid protein VP1 N-terminus (that contains an amphipathic alpha-helix) and capsid protein VP4 are externalized. Together, they shape a pore in the host membrane through which viral genome is translocated to host cell cytoplasm. After genome has been released, the channel shrinks ().
