The Genome Polyprotein Antibody (PACO33948) is a highly specific and sensitive tool for researchers studying viral infections, particularly those caused by viruses with polyproteins as part of their lifecycle. This antibody, produced through a proprietary process, targets the genome polyprotein and allows for its detection and analysis in a variety of samples.This antibody is validated for use in various research applications, including Western blotting and immunofluorescence, and has been shown to exhibit low nonspecific binding and high signal-to-noise ratio. Its high reactivity with the genome polyprotein in different cell types makes it a versatile tool for studies in virology, molecular biology, and infectious disease research.
The genome polyprotein is a key component in the replication and assembly of certain viruses, making it a critical target for understanding viral pathogenesis and developing antiviral therapies. By using the Genome Polyprotein Antibody (PACO33948), researchers can gain valuable insights into the mechanisms of viral infections and potentially identify new strategies for combating viral diseases.
Antibody Name:
Genome polyprotein Antibody (PACO33948)
Antibody SKU:
PACO33948
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Dengue virus type 1
Immunogen:
Recombinant Dengue virus type 1 Genome polyprotein protein
Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA.prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acid, c pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.
Synonyms:
Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
UniProt Protein Function:
Capsid protein C: Plays a role in virus budding by binding to the cell membrane and gathering the viral RNA into a nucleocapsid that forms the core of a mature virus particle (PubMed:11893341). During virus entry, may induce genome penetration into the host cytoplasm after hemifusion induced by the surface proteins. Can migrate to the cell nucleus where it modulates host functions (PubMed:18420804, PubMed:21909430). Overcomes the anti-viral effects of host EXOC1 by sequestering and degrading the latter through the proteasome degradation pathway (PubMed:23522008).
flavivirus polyprotein; anchored capsid protein C; membrane glycoprotein precursor M; membrane glycoprotein M; envelope protein E; nonstructural protein NS1; nonstructural protein NS2A; nonstructural protein NS2B; nonstructural protein NS3; nonstructural protein NS4A; nonstructural protein NS4B; RNA-dependent RNA polymerase NS5; protein 2K
