The GenieFluor Violet 450 Anti-Rat CD45 Antibody (OX-1) (AGEL3036) is a cutting-edge tool for researchers studying rat immune cells and cell signaling pathways. This antibody specifically targets the CD45 protein, a key marker for identifying and characterizing different types of immune cells. With its high affinity and specificity for rat samples, this antibody allows for precise and reliable detection of CD45 in a variety of experimental setups.CD45, also known as the leukocyte common antigen, is a crucial protein involved in immune cell development, activation, and regulation. By targeting CD45 with this antibody, researchers can gain insights into the behavior and function of immune cells in various physiological and pathological conditions.
This antibody is ideal for use in flow cytometry, immunofluorescence, and other immunological assays, enabling detailed studies of immune cell populations and responses.By utilizing the GenieFluor Violet 450 Anti-Rat CD45 Antibody (OX-1) (AGEL3036), researchers can deepen their understanding of immune system function and dysregulation, paving the way for innovative discoveries in immunology, autoimmunity, infectious diseases, and beyond. This antibody is a valuable asset for any laboratory seeking to advance knowledge in the field of immunological research.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P04157
Gene ID:
19265
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD45 is a 180-220 kD protein also known as leukocyte common antigen (LCA). It is a protein tyrosine phosphatase with multiple isoforms differing as a result of alternative splicing of the extracellular domain and glycosylation. CD45 is expressed on all hematopoietic cells except erythrocytes and platelets; isoform expression depends on cell type, activation state, and cell maturation. CD45 functions in signal transduction through T and B cell antigen receptors. CD45 has been shown to interact with various proteins including galectin-1, CD2, CD3, and CD4. The OX-1 antibody has been shown to partially inhibit NK cell-mediated lysis of syngeneic tumor cells in vitro.