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GenieFluor Violet 450 Anti-Mouse CD22 Antibody [Cy34.1] (AGEL3355)

SKU:
AGEL3355
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Mouse
Isotype:
Mouse IgG1, k
Clone:
Cy34.1
Conjugation:
AFViolet 450
€219 - €459
Frequently bought together:

Description

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GenieFluor Violet 450 Anti-Mouse CD22 Antibody [Cy34.1]

The GenieFluor Violet 450 Anti-Mouse CD22 Antibody (Cy34.1) is a cutting-edge tool for researchers studying CD22, a cell surface molecule involved in B cell signaling and development. This antibody, raised against mouse samples, offers high specificity and sensitivity for detecting CD22 in various experimental applications. By binding to the CD22 protein, it enables precise visualization and analysis of CD22 expression in different cell populations, facilitating insights into immune responses and B cell function.CD22, a member of the sialic acid-binding immunoglobulin-like lectins (SIGLEC) family, plays a crucial role in regulating B cell activation and tolerance. Its involvement in modulating B cell receptor signaling makes it a key target for investigating diseases such as leukemia, lymphoma, and autoimmune disorders.

Understanding the functions of CD22 can provide valuable information for developing targeted therapies and immunotherapies that impact B cell-related conditions.Researchers in immunology, oncology, and antibody therapeutics can benefit from the GenieFluor Violet 450 Anti-Mouse CD22 Antibody (Cy34.1) by exploring the intricate mechanisms of CD22-mediated signaling pathways and its implications in disease pathogenesis. With its exceptional performance and reliability, this antibody is an indispensable tool for unraveling the complexities of B cell biology and advancing scientific discoveries in the field of biomedical research.

Product Title:GenieFluor Violet 450 Anti-Mouse CD22 Antibody [Cy34.1]
SKU:AGEL3355
Size:25µg, 100µg
Clone No:Cy34.1
Synonyms:B-cell receptor CD22;Cd22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;Lyb-8; Siglec2;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor Violet 450 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie FluorViolet 450
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P35329
Gene ID:12483
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.

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