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GenieFluor Violet 450 Anti-Mouse CD162 Antibody [4RA10] (AGEL3196)

SKU:
AGEL3196
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG1, k
Clone:
4RA10
Conjugation:
AFViolet 450
$239 - $551
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Description

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GenieFluor Violet 450 Anti-Mouse CD162 Antibody [4RA10]

The GenieFluor Violet 450 Anti-Mouse CD162 Antibody (4RA10) (AGEL3196) offered by Assay Genie is a cutting-edge tool for research involving CD162, a cell surface glycoprotein known for its involvement in cell-cell adhesion and migration processes. This antibody is specifically designed for use in mouse samples, providing high reactivity and specificity. Validated for various applications including flow cytometry and immunofluorescence, the GenieFluor Violet 450 Anti-Mouse CD162 Antibody (4RA10) (AGEL3196) enables precise detection and visualization of CD162 expression in different cell types and tissues.CD162, also referred to as P-selectin glycoprotein ligand-1 (PSGL-1), plays a crucial role in mediating interactions between immune cells and the endothelium, thereby regulating inflammatory responses and immune cell recruitment.

Understanding the functions and regulation of CD162 is essential for unraveling the mechanisms underlying inflammatory diseases, immune cell trafficking, and other physiological processes. By targeting CD162 with this advanced antibody, researchers can delve deeper into the complexities of immune cell interactions and potentially identify new therapeutic targets for conditions such as inflammation, infection, and autoimmune disorders.

Product Title:GenieFluor Violet 450 Anti-Mouse CD162 Antibody [4RA10]
SKU:AGEL3196
Size:25µg, 100µg
Clone No:4RA10
Synonyms:P-selectin glycoprotein ligand 1;Selplg;PSGL-1;Selectin P ligand;CD162;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:Genie Fluor Violet 450 Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:Genie FluorViolet 450
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q62170
Gene ID:20345
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L.

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