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GenieFluor Violet 450 Anti-Mouse CD162 Antibody [4RA10] (AGEL3193)

SKU:
AGEL3193
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG1, k
Clone:
4RA10
Conjugation:
AFViolet 450
€389 - €889
Frequently bought together:

Description

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GenieFluor Violet 450 Anti-Mouse CD162 Antibody [4RA10]

The GenieFluor Violet 450 Anti-Mouse CD162 Antibody (4RA10) is a cutting-edge tool for researchers investigating CD162, a cell surface marker involved in immune cell adhesion and migration processes. This antibody, specifically designed for use in mouse samples, has been meticulously developed and validated for a range of experimental applications, including flow cytometry and immunofluorescence.CD162, also known as PSGL-1 (P-selectin glycoprotein ligand-1), is a crucial player in immune cell interactions with endothelial cells and platelets, mediating inflammatory responses and immune cell trafficking. By targeting CD162 with this highly specific antibody, researchers can gain valuable insights into the role of this molecule in immune system function, inflammation, and various disease processes.

With its exceptional reactivity and reliability in detecting CD162 in mouse samples, the GenieFluor Violet 450 Anti-Mouse CD162 Antibody (4RA10) is an essential tool for studies in immunology, inflammation, and vascular biology. Its application in various research settings makes it an indispensable resource for unraveling the complex mechanisms underlying immune cell adhesion and migration, paving the way for new discoveries in biomedical research.

Product Title:GenieFluor Violet 450 Anti-Mouse CD162 Antibody [4RA10]
SKU:AGEL3193
Size:50 Tests, 100 Tests, 200 Tests
Clone No:4RA10
Synonyms:P-selectin glycoprotein ligand 1;Selplg;PSGL-1;Selectin P ligand;CD162;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:Genie Fluor Violet 450 Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:Genie FluorViolet 450
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q62170
Gene ID:20345
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L.

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