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GenieFluor Violet 450 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410] (AGEL2958)

SKU:
AGEL2958
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Mouse
Rat
Host Species:
Mouse
Isotype:
Mouse IgG1, κ
Clone:
MIAP410
Conjugation:
AFViolet 450
€259 - €749

Description

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GenieFluor Violet 450 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]

The GenieFluor Violet 450 Anti-Human/Mouse/Rat CD47 Antibody (Miap410) (AGEL2958) is a highly specific antibody designed for research applications targeting CD47, a cell surface protein with diverse roles in immune regulation and cancer biology. This monoclonal antibody is developed for use in multiplex flow cytometry, immunofluorescence microscopy, and other related techniques, offering reliable detection and analysis of CD47 expression in various cellular contexts.CD47, also known as integrin-associated protein, is a multifunctional molecule involved in modulating immune responses, cell adhesion, and tumor evasion mechanisms. Its interaction with signal regulatory protein alpha (SIRPα) plays a key role in the regulation of phagocytosis and immune surveillance.

The CD47 antibody (Miap410) provides researchers with a valuable tool to investigate the functions of CD47 in different cell types, aiding in the study of immune evasion strategies employed by cancer cells and potential therapeutic interventions targeting this pathway.With its broad reactivity across human, mouse, and rat samples, this antibody is versatile and suitable for a range of experimental settings. Researchers in the fields of immunology, oncology, and cellular biology can utilize the GenieFluor Violet 450 Anti-CD47 Antibody to deepen their understanding of CD47-mediated processes and explore new avenues for developing targeted therapies against cancer and other diseases where CD47 dysregulation is implicated.

Product Title:GenieFluor Violet 450 Anti-Human/Mouse/Rat CD47 Antibody [MIAP410]
SKU:AGEL2958
Size:20 Tests, 100 Tests, 200 Tests
Clone No:MIAP410
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human;Mouse;Rat
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor Violet 450 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie FluorViolet 450
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q08722 Q61735 P97829
Gene ID:961,16423,29364
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. It is widely expressed on many cell types and often associated with beta 3 integrins. It has been reported that CD47 functions as a self marker. Red cells lacking CD47 were rapidly cleared from the bloodstream by splenic macrophages. By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking.

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