The GenieFluor Violet 450 Anti-Human CD18 Antibody (TS1/18) is a valuable tool designed for research involving the CD18 protein, a crucial component of leukocyte integrins essential for immune cell adhesion and migration. This antibody, with high specificity and sensitivity towards human CD18, is ideal for various immunological studies and flow cytometry applications.CD18, also known as integrin beta-2, is a key player in leukocyte function, mediating interactions between immune cells and endothelial cells during inflammation and immune responses. The GenieFluor Violet 450 Anti-Human CD18 Antibody allows for the precise detection and analysis of CD18 expression on different cell types, aiding in the understanding of immune cell behavior and function in various physiological and pathological conditions.
By enabling researchers to study the role of CD18 in immune cell adhesion, migration, and inflammatory responses, this antibody provides insights that are crucial for unraveling the mechanisms underlying immune-related diseases such as inflammatory disorders, autoimmune conditions, and infectious diseases. Its specificity and reliability make it a valuable asset for immunologists and researchers focused on elucidating the complexities of immune system regulation and function.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P05107
Gene ID:
3689
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD18 is a 90-95 kD type I transmembrane protein also known as integrin β2 subunit, LFA-1 β subunit, and β2 integrin. CD18 non-covalently associates with CD11a, CD11b or CD11c. CD18 is expressed on all leukocytes. CD18 and associated α chains function in adhesion and signaling in hematopoietic cells.