The GenieFluor Violet 450 Anti-Human CD127 (IL-7RA) Antibody (A019D5) offered by Assay Genie is a cutting-edge tool designed for research involving the CD127 antigen, also known as the IL-7 receptor alpha chain. This antibody, optimized for human samples, is a key component in the study of immune cell populations, particularly T cells.The IL-7 receptor plays a crucial role in T cell development, survival, and function, making it a vital target for immunology research. The GenieFluor Violet 450 Anti-Human CD127 antibody enables precise detection and analysis of CD127-expressing cells in various experimental settings, including flow cytometry and immunofluorescence assays.
With its high specificity and sensitivity, this antibody allows researchers to delve into the intricate mechanisms underlying immune responses, making it an invaluable tool for studies on immune disorders, infectious diseases, and cancer biology. By elucidating the functions of CD127, scientists can uncover new therapeutic targets and develop innovative treatments to modulate immune responses effectively. Trust the GenieFluor Violet 450 Anti-Human CD127 Antibody to advance your research and unlock the mysteries of immune regulation.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P16871
Gene ID:
3575
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.