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GenieFluor Red 780 Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL3118)

SKU:
AGEL3118
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
29F.1A12
Conjugation:
AFRed 780
$287 - $647
Frequently bought together:

Description

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GenieFluor Red 780 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The GenieFluorâ„¢ Red 780 Anti-Mouse CD279 (PD-1) Antibody (29F.1A12) is a cutting-edge tool for researchers studying immune checkpoint regulation. This antibody is specifically designed to target the PD-1 protein, a key player in immune system modulation and a promising target for cancer immunotherapy.PD-1, also known as Programmed Cell Death Protein 1, is a receptor expressed on the surface of T cells that helps regulate immune responses. By binding to PD-1, this antibody facilitates the detection and analysis of PD-1 expression in mouse samples. Its high specificity and sensitivity make it an ideal choice for a range of applications, including flow cytometry, immunofluorescence, and immunohistochemistry.

Understanding the role of PD-1 in immune regulation is crucial for developing novel therapeutic strategies for cancer and other immune-related disorders. This antibody provides researchers with a powerful tool to advance their studies in immunology, oncology, and beyond. Explore new avenues of research and uncover the potential of targeting PD-1 in harnessing the immune system for improved clinical outcomes.

Product Title:GenieFluor Red 780 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL3118
Size:25µg, 100µg
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor Red 780 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie FluorRed 780
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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