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GenieFluor Red 780 Anti-Human CD197/CCR7 Antibody [G043H7] (AGEL3063)

SKU:
AGEL3063
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG2a, κ
Clone:
G043H7
Conjugation:
AFRed 780
€259 - €889
Frequently bought together:

Description

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GenieFluor Red 780 Anti-Human CD197/CCR7 Antibody [G043H7]

The GenieFluor Red 780 Anti-Human CD197 (CCR7) Antibody (G043H7) is a cutting-edge tool designed for researchers studying the CD197 antigen, also known as C-C chemokine receptor type 7. This antibody is specially developed to target CD197, a cell surface receptor that plays a pivotal role in immune cell trafficking, particularly in the context of lymphocyte migration and homing within the body.Raised through advanced techniques, this polyclonal antibody offers superior reactivity with human samples, ensuring reliable results in various experimental applications. Validated for use in techniques such as immunofluorescence, flow cytometry, and immunohistochemistry, the GenieFluor Red 780 Anti-Human CD197 (CCR7) Antibody (G043H7) enables precise detection and visualization of CD197-expressing cells in diverse biological samples.By specifically binding to the CD197 protein, this antibody facilitates the investigation and analysis of CCR7-expressing cell populations across different tissues and experimental models.

Its high specificity and sensitivity make it a valuable tool for researchers exploring immune cell migration, lymphoid organ development, and immune responses in health and disease.Researchers focusing on immunology, oncology, or inflammatory disorders will find the GenieFluor Red 780 Anti-Human CD197 (CCR7) Antibody (G043H7) indispensable for unraveling the intricate mechanisms underlying immune cell trafficking and immune system regulation. By delving into the functions of CD197, scientists can gain insights crucial for developing targeted therapies and interventions for conditions involving aberrant immune cell behavior and dysregulated immune responses.

Product Title:GenieFluor Red 780 Anti-Human CD197/CCR7 Antibody [G043H7]
SKU:AGEL3063
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G043H7
Synonyms:CMKBR7; EBI1; EVI1;CCR-7;CDw197;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Genie Fluor Red 780 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Genie FluorRed 780
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P32248
Gene ID:1236
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

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