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GenieFluor Red 780 Anti-Human CD16 Antibody [3G8] (AGEL3000)

SKU:
AGEL3000
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, κ
Clone:
3G8
Conjugation:
AFRed 780
€259 - €889
Frequently bought together:

Description

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GenieFluor Red 780 Anti-Human CD16 Antibody [3G8]

The GenieFluor Red 780 Anti-Human CD16 Antibody (3G8) is a powerful tool for research involving the human CD16 protein, a key receptor present on natural killer (NK) cells and macrophages that plays a crucial role in mediating antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis. This antibody, specifically designed for use in immunology and oncology research, is highly specific and sensitive, enabling precise detection and analysis of CD16 in various cell types.CD16, also known as FcγRIIIA, is a transmembrane glycoprotein that interacts with the Fc portion of immunoglobulins, leading to the activation of immune effector cells and the destruction of target cells. Its role in immune surveillance and anti-tumor immunity makes it a valuable target for studies related to immunotherapy, cancer immunology, and infectious diseases.The GenieFluor Red 780 Anti-Human CD16 Antibody (3G8) provides researchers with a reliable tool for investigating the expression, localization, and function of CD16 in different cellular contexts.

With its high specificity and fluorescence properties, this antibody is well-suited for techniques such as flow cytometry, immunofluorescence, and immunohistochemistry, allowing for detailed analysis and visualization of CD16-expressing cells in complex biological samples.By understanding the mechanisms and regulation of CD16-mediated immune responses, researchers can gain insights into the development of targeted therapies for cancer, infectious diseases, and autoimmune disorders. The GenieFluor Red 780 Anti-Human CD16 Antibody (3G8) offers a valuable solution for unraveling the complexities of CD16 biology and its implications for human health and disease.

Product Title:GenieFluor Red 780 Anti-Human CD16 Antibody [3G8]
SKU:AGEL3000
Size:20 Tests, 100 Tests, 200 Tests
Clone No:3G8
Synonyms:FcγRIII;Fc gamma receptor;Fc gamma receptor 3;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor Red 780 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie FluorRed 780
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P08637 O75015
Gene ID:941
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD16 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD16 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD16 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD16 appears to be expressed later in the immune response than CD86. CD16 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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