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GenieFluor 647 Anti-Mouse IL-17A Antibody [TC11-18H10.1] (AGEL2756)

SKU:
AGEL2756
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
ICFCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG1, κ
Clone:
TC11-18H10.1
Conjugation:
AF647
€199 - €479

Description

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GenieFluor 647 Anti-Mouse IL-17A Antibody [TC11-18H10.1]

The GenieFluorâ„¢ 647 Anti-Mouse IL-17A Antibody (TC11-18H10.1) is a cutting-edge research tool designed for the precise detection and analysis of interleukin-17A (IL-17A) in mouse samples. This antibody, raised against IL-17A, a key cytokine involved in immune responses and inflammation regulation, offers robust reactivity and specificity for IL-17A detection in various experimental applications.IL-17A is a pro-inflammatory cytokine produced by various immune cells, playing a crucial role in host defense against pathogens and the pathogenesis of autoimmune diseases. The GenieFluorâ„¢ 647 Anti-Mouse IL-17A Antibody (TC11-18H10.1) enables researchers to accurately measure IL-17A levels in mouse models, aiding in the understanding of immune responses, inflammatory processes, and potential therapeutic targets for diseases such as arthritis, asthma, and psoriasis.

With its high sensitivity and specificity, this antibody is validated for use in techniques such as immunofluorescence, immunohistochemistry, and flow cytometry, providing valuable insights into the role of IL-17A in immune modulation and disease pathology. Researchers across immunology, inflammation, and autoimmune research fields can leverage the GenieFluorâ„¢ 647 Anti-Mouse IL-17A Antibody (TC11-18H10.1) to advance their studies and pave the way for innovative treatments and interventions targeting IL-17A-associated conditions.

Product Title:GenieFluor 647 Anti-Mouse IL-17A Antibody [TC11-18H10.1]
SKU:AGEL2756
Size:50 Tests, 100 Tests, 200 Tests
Clone No:TC11-18H10.1
Synonyms:Interleukin-17A;IL-17;IL-17A;Cytotoxic T-lymphocyte-associated antigen 8;CTLA-8;CTLA8;
Host Species:Rat
Reactivity:Mouse
Application:ICFCM
Isotype:Rat IgG1, κ
Isotype Control:Genie Fluor 647 Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q62386
Gene ID:16171
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

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