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GenieFluor 647 Anti-Mouse CD163 Antibody [S15049F] (AGEL3398)

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SKU AGEL3398
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2a, k
Clone S15049F
Conjugation AF647
€163 - €413
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Description

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GenieFluor 647 Anti-Mouse CD163 Antibody [S15049F]

The GenieFluor 647 Anti-Mouse CD163 Antibody (S15049F-AGEL3398) is a specialized tool for researchers studying the CD163 protein, a key marker for certain immune cell subsets. This antibody, produced specifically for mouse samples, is optimized for various applications, including immunofluorescence, flow cytometry, and immunohistochemistry.CD163 is a scavenger receptor involved in clearing hemoglobin-haptoglobin complexes and is expressed on macrophages and monocytes. Its role in modulating immune responses and inflammation makes it a valuable target for investigating diseases such as cancer, infectious diseases, and inflammatory disorders.

This high-quality antibody specifically recognizes and binds to CD163 in mouse samples, enabling precise detection and analysis in different experimental settings. By facilitating the study of CD163 expression and function, researchers can deepen their understanding of immune cell behavior and potentially uncover new therapeutic strategies.

Product Title:GenieFluor 647 Anti-Mouse CD163 Antibody [S15049F]
SKU:AGEL3398
Size:25µg, 100µg
Clone No:S15049F
Synonyms:M130; MM130; SCARI1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 647 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q2VLH6
Gene ID:93671
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammatory diseases.

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