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GenieFluor 647 Anti-Human CD127/IL-7RA Antibody [A019D5] (AGEL2279)

SKU:
AGEL2279
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, κ
Clone:
A019D5
Conjugation:
AF647
€269 - €879

Description

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GenieFluor 647 Anti-Human CD127/IL-7RA Antibody [A019D5]

The GenieFluor 647 Anti-Human CD127 (IL-7Ra) Antibody (A019D5) is a cutting-edge tool designed for researchers delving into the intricacies of the IL-7 receptor alpha chain (CD127), a crucial component in immune cell functions and homeostasis. This antibody, meticulously crafted to target human samples, facilitates precise detection and analysis of CD127 expression in various cell types.Within the realm of immunology and beyond, the IL-7 receptor plays a pivotal role in regulating immune responses, cell survival, and differentiation. By specifically binding to CD127, the GenieFluor 647 Anti-Human CD127 (IL-7Ra) Antibody enables researchers to delve deeper into the molecular mechanisms governing immune cell behavior and the development of potential therapeutic interventions.

With its versatility in applications such as flow cytometry and immunofluorescence, this antibody opens avenues for comprehensive investigations into immune-related disorders, autoimmune diseases, and cancer research. Harnessing the power of this advanced antibody, scientists can unravel the intricate workings of the IL-7 receptor alpha chain, paving the way for innovative discoveries and novel therapeutic targets in the realm of immunology and disease research.

Product Title:GenieFluor 647 Anti-Human CD127/IL-7RA Antibody [A019D5]
SKU:AGEL2279
Size:20 Tests, 100 Tests, 200 Tests
Clone No:A019D5
Synonyms:Interleukin-7 receptor subunit alpha;IL-7RA;CDw127;CD127;IL-7Rα;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor 647 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P16871
Gene ID:3575
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.

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