The GenieFluor 488 Anti-Mouse LY6A/E (Sca-1) Antibody (D7) is a powerful tool for researchers studying cell surface markers and stem cell biology. This antibody is specifically designed to target LY6A/E, also known as Sca-1, a marker commonly used to identify and isolate stem and progenitor cells in mice.By using the GenieFluor 488 Anti-Mouse LY6A/E (Sca-1) Antibody (D7), researchers can accurately detect and analyze LY6A/E expression in various mouse cell types, providing invaluable insights into stem cell populations and their characteristics. This antibody is validated for use in applications such as flow cytometry and immunofluorescence, offering researchers flexibility in experimental design.LY6A/E, a well-established marker for stem cells, plays a crucial role in identifying and studying these regenerative cell populations.
By targeting LY6A/E with high specificity and sensitivity, the GenieFluor 488 Anti-Mouse LY6A/E (Sca-1) Antibody (D7) enables precise detection of these important cells in mouse models, supporting research in areas such as developmental biology, regenerative medicine, and cancer stem cell biology.For researchers looking to delve deeper into stem cell biology and explore the potential of stem cells in various research applications, the GenieFluor 488 Anti-Mouse LY6A/E (Sca-1) Antibody (D7) provides a reliable and effective tool for accurate detection and analysis of LY6A/E expression in mouse stem and progenitor cells.
Genie Fluor 488 Rat IgG2a, κ Isotype Control[2A3]
Form:
Liquid
Conjugation:
Genie Fluor488
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P05533
Gene ID:
110454
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
Ly-6A/E, also known as Sca-1, is an 18 kD member of the Ly-6 multigene family. Ly6A/E is a glycosylphosphatidylinositol (GPI)-linked protein expressed on hematopoietic stem cells. In mice expressing the Ly-6.2 haplotype (e.g., AKR, C57BL, C57BR, DBA/2, SJL, SWR, and 129), Ly-6A/E is also expressed on peripheral B lymphocytes and thymic and peripheral T lymphocytes. Strains expressing the Ly-6.1 haplotype (e.g., BALB/c, CBA, C3H/He, DBA/1, and NZB) have low Ly-6A/E expression on resting peripheral lymphocytes. The expression of Ly-6A/E on lymphocytes is upregulated upon activation from both Ly6.1 and Ly6.2 haplotype mice. Ly-6A/E is thought to be involved in the regulation of both T and B cell responses.