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GenieFluor 488 Anti-Mouse CD274/PD-L1 Antibody [10F.9G2] (AGEL3323)

SKU:
AGEL3323
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2b, k
Clone:
10F.9G2
Conjugation:
AF488
€269 - €609
Frequently bought together:

Description

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GenieFluor 488 Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]

The GenieFluor 488 Anti-Mouse CD274 (PD-L1) Antibody (10F.9G2) is a cutting-edge research tool designed for the detection and analysis of CD274 (PD-L1), an important cell surface protein involved in immune regulation. This antibody, specifically developed for use with mouse samples, offers high reactivity and specificity, ensuring reliable results in a variety of experimental applications.CD274, also known as programmed death-ligand 1 (PD-L1), is a key immune checkpoint protein that plays a crucial role in modulating immune responses and maintaining self-tolerance. Its interaction with programmed death 1 (PD-1) on T cells is a major mechanism through which cancer cells evade immune surveillance, making CD274 a promising target for immunotherapy development.

By enabling precise detection and analysis of CD274 in mouse samples, the GenieFluor 488 Anti-Mouse CD274 (PD-L1) Antibody (10F.9G2) facilitates in-depth research into immune checkpoint pathways, cancer immunology, and therapeutic development. With its validated performance in various experimental techniques, this antibody is an invaluable tool for scientists and researchers striving to advance our understanding of immune regulation and develop novel treatments for cancer and other immune-related disorders.

Product Title:GenieFluor 488 Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]
SKU:AGEL3323
Size:25µg, 100µg
Clone No:10F.9G2
Synonyms:B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Genie Fluor 488 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q9EP73
Gene ID:60533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

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