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GenieFluor 488 Anti-Mouse CD117 Antibody [2B8] (AGEL2181)

SKU:
AGEL2181
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2b, κ
Clone:
2B8
Conjugation:
AF488
€199 - €409
Frequently bought together:

Description

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GenieFluor 488 Anti-Mouse CD117 Antibody [2B8]

The GenieFluor 488 Anti-Mouse CD117 Antibody (2B8) - AGEL2181 is a powerful tool for researchers studying CD117, also known as c-kit, a protein that plays a crucial role in cell signaling and differentiation. This antibody, specifically designed for use in mouse samples, is highly selective and sensitive, allowing for precise detection and analysis in various experimental settings.CD117 is a transmembrane receptor tyrosine kinase that is involved in the development and function of various cell types, including hematopoietic stem cells, melanocytes, and germ cells. Its dysregulation has been implicated in a range of diseases, including cancer, gastrointestinal stromal tumors (GISTs), and mastocytosis.

The ability to detect and study CD117 expression using this antibody is essential for understanding its role in both normal physiology and disease processes.With its outstanding performance in applications such as immunofluorescence, flow cytometry, and immunohistochemistry, the GenieFluor 488 Anti-Mouse CD117 Antibody (2B8) - AGEL2181 is a valuable addition to any research toolkit focused on investigating the function and regulation of CD117 in biological systems.

Product Title:GenieFluor 488 Anti-Mouse CD117 Antibody [2B8]
SKU:AGEL2181
Size:25µg, 100µg
Clone No:2B8
Synonyms:Mast/stem cell growth factor receptor Kit;Kit;SCFR;Proto-oncogene c-Kit;Tyrosine-protein kinase Kit;CD117;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Genie Fluor 488 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P05532
Gene ID:16590
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD117 is a 145 kD immunoglobulin superfamily member also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.

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