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GenieFluor 488 Anti-Human CD22 Antibody [BU59] (AGEL3205)

SKU:
AGEL3205
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, k
Clone:
BU59
Conjugation:
AF488
€209 - €709

Description

GenieFluor 488 Anti-Human CD22 Antibody [BU59]

The GenieFluor 488 Anti-Human CD22 Antibody (BU59) offered by Assay Genie is a powerful tool for research into CD22, a cell surface glycoprotein primarily expressed on B lymphocytes. This highly-specific antibody is designed for use in various immunoassays, including flow cytometry and immunofluorescence, enabling precise detection and analysis of CD22 expression in human samples.CD22 is a key regulator of B cell activation and function, playing a vital role in the development and modulation of immune responses. Its involvement in B cell signaling pathways and antibody production makes it a crucial target for studies in immunology, autoimmunity, and hematological malignancies.

The GenieFluor 488 Anti-Human CD22 Antibody (BU59) facilitates detailed investigation into the role of CD22 in these processes, providing researchers with a valuable tool to advance their understanding of B cell biology and related disorders.With its high specificity, sensitivity, and versatility in various experimental applications, this antibody from Assay Genie is a reliable choice for researchers seeking to unravel the intricate mechanisms of CD22-mediated immune responses and their implications in health and disease.

Product Name:AF488 Anti-Human CD22 Antibody [BU59]
Product Code:AGEL3205
Size:20 Tests, 100 Tests, 200 Tests
Clone No:BU59
Synonyms:B-cell receptor CD22, Cd22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14, CD22, Lyb-8, Siglec2
Reactivity:Human
Host Species:Mouse
Applications:FCM
Isotype:Mouse IgG1, κ
Isotype Control:AF488 Mouse IgG1, κ Isotype Control [MOPC-21]
Conjugation:AF488
Applications:FCM
Recommended Dilution:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage:Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Fluorescent Label:GenieFluor 488 is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 520 nm (e.g., a 525/40 nm bandpass filter).
Shipping:Biological ice pack at 4°C
Form:Liquid
Swissprot:P20273
Background Information:CD22 is a 130 kD type I transmembrane glycoprotein also known as Siglec-2 and BL-CAM. It is a member of the immunoglobulin superfamily (sialoadhesion subgroup). CD22 is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B and activated B cells, but not on plasma cells. CD22 is present in the B cell receptor complex and associates with SHP-1, Syk, Lck, Lyn, and phospholipase Cγ1. A primary function of CD22 is thought to be in limiting antigen receptor signaling by modulating B cell activation threshold. CD22 has been shown to bind to CD45RO and CD75, although the natural ligands for this molecule remain controversial.

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