The Gen1 Polyclonal Antibody (CAB10001) is a versatile tool for researchers studying the CD300A protein, a cell surface molecule with important implications in immune regulation. This antibody, raised in rabbits, boasts high reactivity with human samples and is ideal for use in Western blot applications. By specifically binding to the CD300A protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a valuable asset for studies in immunology and cancer research.CD300A, also referred to as an immune inhibitory receptor, plays a crucial role in maintaining immune homeostasis by regulating inflammation and suppressing allergic responses.
Its involvement in modulating immune reactions positions it as a key focus for investigations into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. A thorough understanding of CD300A's function is essential for the development of targeted therapies that manipulate or enhance immune responses in these disease contexts.Overall, the Gen1 Polyclonal Antibody (CAB10001) serves as a reliable tool for researchers seeking to explore the role of CD300A in immune regulation and its potential implications for various disease states.
Product Name:
GEN1 Rabbit Polyclonal Antibody
SKU:
CAB10001
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 669-908 of human GEN1 (NP_872431.3).
This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
348654
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GEN1 antibody (CAB10001) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
