GEN1 Rabbit Polyclonal Antibody (CAB10001)
- SKU:
- CAB10001
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | GEN1 Rabbit Polyclonal Antibody |
SKU: | CAB10001 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 669-908 of human GEN1 (NP_872431.3). |
Sequence: | LQDL PLKE RIFT KLSY PQDN LQPD VNLK TLSI LSVK ESCI ANSG SDCT SHLS KDLP GIPL QNES RDSK ILKG DQLL QEDY KVNT SVPY SVSN TVVK TCNV RPPN TALD HSRK VDMQ TTRK ILMK KSVC LDRH SSDE QSAP VFGK AKYT TQRM KHSS QKHN SSHF KESG HNKL SSPK IHIK ETEQ CVRS YETA ENEE SCFP DSTK SSLS SLQC HKKE NNSG TCLD SPLP LRQR LKLR FQST |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | Gen; GEN1 |
Positive Sample: | H460,MCF-7,Mouse thymus,Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 103kDa |
Observed MW: | 103kDa |
This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 348654 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |