The Gemin7 Polyclonal Antibody (CAB15189) is a crucial tool for researchers studying Gemin7, a key protein involved in RNA processing and regulation of gene expression. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the Gemin7 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for studies in molecular biology and gene expression research.Gemin7 is known to play a critical role in the assembly of the Smn complex, which is essential for the biogenesis of small nuclear ribonucleoproteins (snRNPs) and the splicing of pre-mRNA.
Dysregulation of Gemin7 has been linked to various diseases, including spinal muscular atrophy (SMA) and other neurodegenerative disorders. By understanding the function and regulation of Gemin7, researchers can gain valuable insights into these diseases and potentially identify new therapeutic targets for treatment.Overall, the Gemin7 Polyclonal Antibody is a valuable tool for researchers interested in unraveling the complex mechanisms of RNA processing and gene expression, with potential implications for the development of novel therapies for genetic disorders and other diseases.
Product Name:
GEMIN7 Rabbit Polyclonal Antibody
SKU:
CAB15189
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-131 of human GEMIN7 (NP_078983.1).
The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
79760
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using GEMIN7 Rabbit pAb (CAB15189) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
