The Gemini2 Polyclonal Antibody (CAB3082) is a versatile tool for research involving the Gemini2 protein, a key player in cell cycle regulation and DNA replication. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the Gemini2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for studies in molecular biology and cancer research.Gemini2, also known as WDR92, is essential for the proper functioning of the cell cycle and is involved in maintaining genomic stability. Dysregulation of Gemini2 has been implicated in various types of cancer, making it a promising target for therapeutic interventions.
By investigating the role of Gemini2 in DNA replication and cell division, researchers can gain valuable insights into the mechanisms underlying cancer development and progression.Overall, the Gemini2 Polyclonal Antibody (CAB3082) offers researchers a reliable tool for studying the function of Gemini2 and its implications in cancer biology. Its high specificity and sensitivity make it an invaluable asset for research efforts aimed at understanding the molecular mechanisms governing cell cycle progression and DNA replication.
Product Name:
Gemin 2 Rabbit Polyclonal Antibody
SKU:
CAB3082
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 180-280 of human Gemin 2 (NP_003607.1)
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
Purification Method:
Affinity purification
Gene ID:
8487
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells, using Gemin 2 Rabbit pAb (CAB3082) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
