The Gelsolin Polyclonal Antibody (CAB2952) is a vital tool for researchers studying the protein gelsolin, which plays a crucial role in cytoskeletal remodeling, cell motility, and apoptosis regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting human samples, making it an excellent choice for Western blot analysis.Gelsolin is a multifunctional protein that binds to actin filaments, severing them and regulating actin dynamics in cells. Dysregulation of gelsolin has been linked to various pathological conditions, including cancer metastasis, neurodegenerative diseases, and inflammatory disorders.
By targeting gelsolin with this antibody, researchers can gain insights into its function and potential therapeutic applications.This antibody enables the detection and quantification of gelsolin in a variety of cell types and tissues, making it a valuable tool for studies in cell biology, cancer research, and neurology. Understanding the role of gelsolin in cellular processes is essential for unraveling its implications in health and disease, paving the way for innovative treatments and interventions.
Product Name:
Gelsolin Rabbit Polyclonal Antibody
SKU:
CAB2952
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 543-782 of human Gelsolin (NP_000168.1).
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2934
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Gelsolin antibody (CAB2952) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
