The GDPD2 Polyclonal Antibody (PAC040614) is a crucial tool for researchers studying GDPD2, a member of the glycerophosphodiester phosphodiesterase family involved in lipid metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By binding to the GDPD2 protein, this antibody enables precise detection and analysis in various cell types, making it an essential component for investigations in lipid metabolism and related research fields.
GDPD2 is a key player in lipid homeostasis, playing a vital role in lipid metabolism and signaling pathways. Dysregulation of GDPD2 has been linked to various metabolic disorders and diseases, making it a promising target for research into conditions such as obesity, diabetes, and cardiovascular diseases. Understanding the function of GDPD2 is crucial for developing novel therapeutic strategies that target lipid metabolism pathways for the treatment of these health issues.
Western blot. All lanes: GDPD2 antibody at 1.5µg/ml + A431 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 62, 53, 67 kDa. Observed band size: 62 kDa.
Immunohistochemistry of paraffin-embedded human liver cancer using PACO40614 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO40614 at dilution of 1:100.
Background:
Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4-phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton (By similarity).
GDPD2: Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4- phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton. Belongs to the glycerophosphoryl diester phosphodiesterase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Phosphodiesterase; EC 3.1.4.43Chromosomal Location of Human Ortholog: Xq13.1
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. This protein may have a role in osteoblast differentiation and growth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
