The GDNF Polyclonal Antibody (CAB14639) is a valuable tool for researchers studying Glial Cell Line-Derived Neurotrophic Factor (GDNF) in various biological processes. This antibody, generated in rabbits, is highly specific for detecting GDNF in human samples and is validated for use in Western blot applications.GDNF is a neurotrophic factor that plays a crucial role in promoting the survival and maintenance of various neuronal populations, making it a key target in research on neurodegenerative diseases such as Parkinson's disease. This antibody binds to GDNF, allowing for accurate detection and analysis in different cell types.
Its high specificity and sensitivity make it an ideal choice for studies in neuroscience, cell biology, and drug development targeting GDNF pathways.By utilizing the GDNF Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying neuronal survival and development, as well as explore potential therapeutic strategies for neurodegenerative disorders and other conditions involving GDNF signaling pathways. This antibody is a vital tool for advancing our understanding of GDNF function and its implications in various biological processes.
Product Name:
GDNF Rabbit Polyclonal Antibody
SKU:
CAB14639
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 109-211 of human GDNF (NP_000505.1).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing.
Purification Method:
Affinity purification
Gene ID:
2668
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GDNF Rabbit pAb (CAB14639) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
