GDNF Rabbit Polyclonal Antibody (CAB14639)
- SKU:
- CAB14639
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | GDNF Rabbit Polyclonal Antibody |
SKU: | CAB14639 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 109-211 of human GDNF (NP_000505.1). |
Sequence: | RGQR GKNR GCVL TAIH LNVT DLGL GYET KEEL IFRY CSGS CDAA ETTY DKIL KNLS RNRR LVSD KVGQ ACCR PIAF DDDL SFLD DNLV YHIL RKHS AKRC GCI |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | ATF; ATF1; ATF2; HSCR3; HFB1-GDNF; GDNF |
Positive Sample: | Mouse brain,Mouse kidney,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 24kDa |
Observed MW: | 24kDa |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing.
Purification Method: | Affinity purification |
Gene ID: | 2668 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |