The GDF9 Polyclonal Antibody (CAB2739) is a vital tool for researchers studying growth differentiation factor 9 (GDF9), a protein involved in ovarian development and folliculogenesis. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in applications such as Western blotting. By specifically binding to the GDF9 protein, this antibody allows for the detection and analysis of GDF9 in various cell types, making it ideal for investigations in reproductive biology and fertility research.
GDF9 is a key player in the regulation of folliculogenesis and oocyte maturation, making it a critical factor in female reproductive health. Its importance in ovarian function and fertility makes it a promising target for research into conditions such as infertility and polycystic ovary syndrome. By understanding the role of GDF9, researchers can potentially uncover new therapeutic approaches for addressing reproductive disorders and improving fertility outcomes.
Product Name:
GDF9 Rabbit Polyclonal Antibody
SKU:
CAB2739
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 205-454 of human GDF9 (NP_005251.1).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Reduced expression of this gene may be associated with polycystic ovary syndrome and mutations in this gene may be more common in mothers of dizygotic twins.
Purification Method:
Affinity purification
Gene ID:
2661
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of SH-SY5Y cells, using GDF9 antibody (CAB2739) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
