The GDF7 Polyclonal Antibody (PACO17981) is an essential tool for researchers studying GDF7, a member of the TGF-β superfamily of cytokines that plays a crucial role in skeletal development and maintenance. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.GDF7, also known as growth and differentiation factor 7, is involved in the regulation of bone density and cartilage formation, making it a key target for studies in orthopedics and musculoskeletal biology. By detecting and analyzing GDF7 protein expression in various cell types, this antibody enables researchers to investigate its role in skeletal development, repair, and regeneration processes.
The insights gained from research on GDF7 have the potential to impact the development of therapies for bone and joint disorders, such as osteoporosis and osteoarthritis. By elucidating the mechanisms by which GDF7 influences skeletal health, researchers can pave the way for new treatment strategies that aim to promote bone and cartilage regeneration and slow the progression of degenerative musculoskeletal conditions.
Antibody Name:
GDF7 Antibody (PACO17981)
Antibody SKU:
PACO17981
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human GDF7
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 6%SDS-PAGE,Lysate: 40 μg,,Primary antibody: PACO17981(GDF7 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 3 minutes.
Background:
This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-β superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord.
Synonyms:
growth differentiation factor 7
UniProt Protein Function:
GDF7: May play an active role in the motor area of the primate neocortex. Belongs to the TGF-beta family.
UniProt Protein Details:
Protein type:Cytokine; Secreted; Secreted, signal peptide; Cell development/differentiation
Chromosomal Location of Human Ortholog: 2p24.1
Cellular Component: extracellular space
Molecular Function:cytokine activity; growth factor activity; protein binding; protein homodimerization activity; transforming growth factor beta receptor binding
Biological Process: activin receptor signaling pathway; axon guidance; BMP signaling pathway; branching morphogenesis of a tube; cell development; cell fate commitment; epithelial cell differentiation; forebrain morphogenesis; gland morphogenesis; growth; midbrain development; positive regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade; reproductive structure development; roof plate formation; spinal cord association neuron differentiation
NCBI Summary:
This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord. [provided by RefSeq, Jul 2008]
