GDF6 Antibody (PACO17980)
- SKU:
- PACO17980
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
GDF6 Antibody (PACO17980)
The GDF6 Polyclonal Antibody (PAC017980) is a versatile tool for research into Growth Differentiation Factor 6 (GDF6), a protein involved in the regulation of cell growth and differentiation. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications.GDF6, a member of the bone morphogenetic protein (BMP) family, plays a key role in skeletal development and joint formation. Dysregulation of GDF6 has been linked to skeletal disorders, making it a promising target for studies in orthopedics and musculoskeletal research.
The GDF6 antibody binds specifically to the GDF6 protein, enabling precise detection and analysis in various cell types and tissues.By investigating the function and expression of GDF6, researchers can gain valuable insights into the mechanisms underlying bone and joint development, as well as potential therapeutic targets for conditions such as osteoporosis and osteoarthritis. The GDF6 Polyclonal Antibody offers a reliable tool for advancing our understanding of GDF6 biology and its implications for human health.
| Antibody Name: | GDF6 Antibody (PACO17980) |
| Antibody SKU: | PACO17980 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human GDF6 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO17980(GDF6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal muscle tissue, Primary antibody: PACO17980(GDF6 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO17980(GDF6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-β superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. |
| Synonyms: | growth differentiation factor 6 |
| UniProt Protein Function: | GDF6: Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Defects in GDF6 are the cause of Klippel-Feil syndrome type 1 (KFS1). A skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. Deafness is a well- known feature of KFS and may be of sensorineural, conductive, or mixed type. A chromosomal aberration involving GDF6 has been found in a patient with Klippel-Feil syndrome (KFS). Paracentric inv(8)(q22;2q23.3). Defects in GDF6 are the cause of microphthalmia isolated type 4 (MCOP4). A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Cytokine; Cell development/differentiation; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 8q22.1 Cellular Component: extracellular space Molecular Function:cytokine activity; growth factor activity; protein homodimerization activity; transforming growth factor beta receptor binding Biological Process: activin receptor signaling pathway; apoptosis; BMP signaling pathway; cell development; growth; positive regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade Disease: Klippel-feil Syndrome 1, Autosomal Dominant; Leber Congenital Amaurosis 17; Microphthalmia, Isolated 4; Microphthalmia, Isolated, With Coloboma 6 |
| NCBI Summary: | This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6KF10 |
| NCBI GenInfo Identifier: | 74748876 |
| NCBI Gene ID: | 392255 |
| NCBI Accession: | Q6KF10.1 |
| UniProt Secondary Accession: | Q6KF10,Q6PI58, |
| UniProt Related Accession: | Q6KF10 |
| Molecular Weight: | 50,662 Da |
| NCBI Full Name: | Growth/differentiation factor 6 |
| NCBI Synonym Full Names: | growth differentiation factor 6 |
| NCBI Official Symbol: | GDF6Â Â |
| NCBI Official Synonym Symbols: | KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; LCA17; MCOP4; SCDO4; BMP-13; MCOPCB6Â Â |
| NCBI Protein Information: | growth/differentiation factor 6 |
| UniProt Protein Name: | Growth/differentiation factor 6 |
| UniProt Synonym Protein Names: | Bone morphogenetic protein 13; BMP-13; Growth/differentiation factor 16 |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | GDF6Â Â |
| UniProt Entry Name: | GDF6_HUMAN |
| Antibodies | ELISA Kits |
| GDF6 Antibody (PACO06926) | Human GDF6 ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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