GDF6 Antibody (PACO17979)
- SKU:
- PACO17979
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
GDF6 Antibody (PACO17979)
The GDF6 Polyclonal Antibody (PAC017979) is a valuable tool for researchers studying growth differentiation factor 6 (GDF6), a member of the bone morphogenetic protein (BMP) family. This antibody, produced in rabbits, is highly specific for GDF6 and has been validated for use in various applications, including Western blot and immunohistochemistry.GDF6 is known for its role in skeletal development and joint formation, making it a key target for studies related to bone and cartilage biology. It has also been implicated in the regulation of cell growth and differentiation, suggesting its potential relevance in cancer research.
By binding specifically to GDF6, this antibody enables precise detection and analysis of the protein in a variety of sample types, making it an essential tool for researchers in the fields of developmental biology, orthopedics, and oncology.Understanding the function of GDF6 is essential for elucidating its role in normal physiology and disease processes. By utilizing the GDF6 Polyclonal Antibody, researchers can advance our knowledge of GDF6's mechanisms of action and potentially uncover new therapeutic targets for conditions involving skeletal abnormalities or dysregulation of cell growth pathways.
| Antibody Name: | GDF6 Antibody (PACO17979) |
| Antibody SKU: | PACO17979 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human GDF6 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal liver tissue, Human bladder carcinoma tissue, Primary antibody: PACO17979(GDF6 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO17979(GDF6 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-β superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. |
| Synonyms: | growth differentiation factor 6 |
| UniProt Protein Function: | GDF6: Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Defects in GDF6 are the cause of Klippel-Feil syndrome type 1 (KFS1). A skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. Deafness is a well- known feature of KFS and may be of sensorineural, conductive, or mixed type. A chromosomal aberration involving GDF6 has been found in a patient with Klippel-Feil syndrome (KFS). Paracentric inv(8)(q22;2q23.3). Defects in GDF6 are the cause of microphthalmia isolated type 4 (MCOP4). A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Cytokine; Cell development/differentiation; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 8q22.1 Cellular Component: extracellular space Molecular Function:cytokine activity; growth factor activity; protein homodimerization activity; transforming growth factor beta receptor binding Biological Process: activin receptor signaling pathway; apoptosis; BMP signaling pathway; cell development; growth; positive regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade Disease: Klippel-feil Syndrome 1, Autosomal Dominant; Leber Congenital Amaurosis 17; Microphthalmia, Isolated 4; Microphthalmia, Isolated, With Coloboma 6 |
| NCBI Summary: | This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6KF10 |
| NCBI GenInfo Identifier: | 74748876 |
| NCBI Gene ID: | 392255 |
| NCBI Accession: | Q6KF10.1 |
| UniProt Secondary Accession: | Q6KF10,Q6PI58, |
| UniProt Related Accession: | Q6KF10 |
| Molecular Weight: | 50,662 Da |
| NCBI Full Name: | Growth/differentiation factor 6 |
| NCBI Synonym Full Names: | growth differentiation factor 6 |
| NCBI Official Symbol: | GDF6Â Â |
| NCBI Official Synonym Symbols: | KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; LCA17; MCOP4; SCDO4; BMP-13; MCOPCB6Â Â |
| NCBI Protein Information: | growth/differentiation factor 6 |
| UniProt Protein Name: | Growth/differentiation factor 6 |
| UniProt Synonym Protein Names: | Bone morphogenetic protein 13; BMP-13; Growth/differentiation factor 16 |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | GDF6Â Â |
| UniProt Entry Name: | GDF6_HUMAN |
| Antibodies | ELISA Kits |
| GDF6 Antibody (PACO06926) | Human GDF6 ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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