GDF6 Antibody (PACO06926)
- SKU:
- PACO06926
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
GDF6 Antibody (PACO06926)
The GDF6 Polyclonal Antibody (PACO06926) is a valuable tool for researchers studying GDF6, a member of the bone morphogenetic protein family that plays a critical role in skeletal development and maintenance. This antibody, produced in rabbits, is highly specific to human samples and is suitable for use in Western blot applications. By binding to the GDF6 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component of research projects in the fields of orthopedics, musculoskeletal biology, and developmental biology.
GDF6, also known as bone morphogenetic protein 13 (BMP-13), is a key regulator of bone and cartilage formation, making it a promising target for investigations into skeletal disorders, such as osteoarthritis and osteoporosis. By studying the function of GDF6, researchers can gain valuable insights into the underlying mechanisms of these conditions and potential therapeutic interventions. The GDF6 Polyclonal Antibody is a valuable tool for unlocking the mysteries of skeletal biology and advancing knowledge in this important area of research.
| Antibody Name: | GDF6 Antibody (PACO06926) |
| Antibody SKU: | PACO06926 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the Internal region of human GDF-6. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of rat kidney cells using GDF-6 Polyclonal Antibody. |
 | Western Blot analysis of RAT-kidney cells using GDF-6 Polyclonal Antibody. |
| Synonyms: | GDF6; GDF16; Growth/differentiation factor 6; GDF-6; Growth/differentiation factor 16 |
| UniProt Protein Function: | GDF6: Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Defects in GDF6 are the cause of Klippel-Feil syndrome type 1 (KFS1). A skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. Deafness is a well- known feature of KFS and may be of sensorineural, conductive, or mixed type. A chromosomal aberration involving GDF6 has been found in a patient with Klippel-Feil syndrome (KFS). Paracentric inv(8)(q22;2q23.3). Defects in GDF6 are the cause of microphthalmia isolated type 4 (MCOP4). A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Cytokine; Cell development/differentiation; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 8q22.1 Cellular Component: extracellular space Molecular Function:cytokine activity; growth factor activity; protein homodimerization activity; transforming growth factor beta receptor binding Biological Process: activin receptor signaling pathway; apoptosis; BMP signaling pathway; cell development; growth; positive regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade Disease: Klippel-feil Syndrome 1, Autosomal Dominant; Leber Congenital Amaurosis 17; Microphthalmia, Isolated 4; Microphthalmia, Isolated, With Coloboma 6 |
| NCBI Summary: | This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6KF10 |
| NCBI GenInfo Identifier: | 74748876 |
| NCBI Gene ID: | 392255 |
| NCBI Accession: | Q6KF10.1 |
| UniProt Secondary Accession: | Q6KF10,Q6PI58, |
| UniProt Related Accession: | Q6KF10 |
| Molecular Weight: | 50,662 Da |
| NCBI Full Name: | Growth/differentiation factor 6 |
| NCBI Synonym Full Names: | growth differentiation factor 6 |
| NCBI Official Symbol: | GDF6Â Â |
| NCBI Official Synonym Symbols: | KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; LCA17; MCOP4; SCDO4; BMP-13; MCOPCB6Â Â |
| NCBI Protein Information: | growth/differentiation factor 6 |
| UniProt Protein Name: | Growth/differentiation factor 6 |
| UniProt Synonym Protein Names: | Bone morphogenetic protein 13; BMP-13; Growth/differentiation factor 16 |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | GDF6Â Â |
| UniProt Entry Name: | GDF6_HUMAN |
| ELISA Kits |
| Human GDF6 ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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