The GDF5 Polyclonal Antibody (CAB13167) is a valuable tool for research involving Growth Differentiation Factor 5 (GDF5), a protein that belongs to the bone morphogenetic protein (BMP) family and plays a crucial role in skeletal development and joint formation. This antibody, raised in rabbits, shows high specificity and sensitivity towards human samples, making it suitable for use in various applications such as Western blot, immunohistochemistry, and flow cytometry.GDF5 is known for its involvement in the regulation of cartilage and bone formation, making it a promising target for studies related to musculoskeletal disorders, skeletal development abnormalities, and osteoarthritis.
By using the GDF5 Polyclonal Antibody, researchers can detect and analyze GDF5 expression in different cell types and tissues, providing valuable insights into its function and potential therapeutic applications in orthopedic and rheumatologic research.Overall, the GDF5 Polyclonal Antibody is a reliable tool for scientists interested in exploring the role of GDF5 in skeletal biology and joint health, offering a deeper understanding of its mechanisms and pathways for the development of novel treatments and interventions in musculoskeletal diseases.
Product Name:
GDF5 Rabbit Polyclonal Antibody
SKU:
CAB13167
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human GDF5 (NP_000548.2).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis.
Purification Method:
Affinity purification
Gene ID:
8200
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GDF5 Rabbit pAb (CAB13167) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
