The GDF5 Polyclonal Antibody (PAC026937) is specifically designed for research involving Growth Differentiation Factor 5 (GDF5), a protein known to play a key role in skeletal and joint development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.GDF5 is a member of the bone morphogenetic protein family and is involved in various cellular processes including cell growth, differentiation, and development. Its role in promoting bone and cartilage formation makes it a critical target for research in musculoskeletal disorders such as osteoarthritis and skeletal dysplasia.
By targeting the GDF5 protein, this antibody enables the detection and analysis of GDF5 expression in a variety of cell types, making it an invaluable tool for studying skeletal development, joint diseases, and potential therapeutic interventions. Gain a deeper understanding of GDF5's functions and implications in skeletal biology with the use of this high-quality polyclonal antibody.
Antibody Name:
Gdf5 Antibody (PACO26937)
Antibody SKU:
PACO26937
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:10-1:100
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse Growth/differentiation factor 5 protein (376-495AA)
Immunohistochemistry of paraffin-embedded mouse liver tissue using PACO26937 at dilution of 1:50.
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO26937 at dilution of 1:20.
Background:
Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B
Synonyms:
Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14), Gdf5, Bmp14 Bp Gdf-5
UniProt Protein Function:
GDF5: a cytokine that is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. These cytokines are characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Binds to bone morphogenetic protein receptors (BMPRs), a family of transmembrane serine/threonine kinases. BMPRs are involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. Defects in GDF5 are the cause of acromesomelic chondrodysplasia Grebe type (AMDG), acromesomelic chondrodysplasia Hunter-Thompson type (AMDH), brachydactyly type C (BDC), Du Pan syndrome (DPS), symphalangism proximal syndrome (SYM1), multiple synostoses syndrome type 2 (SYNS2), and brachydactyly type A2 (BDA2). Genetic variations in GDF5 are associated with susceptibility to osteoarthritis type 5 (OS5). Belongs to the TGF-beta family.
