The GDF15 Polyclonal Antibody (CAB0185) is a specialized tool for researchers studying Growth Differentiation Factor 15 (GDF15), a protein known for its roles in inflammation, cancer, and metabolic regulation. This antibody, generated in rabbits, is highly specific to human samples and is optimized for Western blot applications.GDF15 is a key biomarker for various diseases, including cancer, cardiovascular disease, and metabolic disorders. Its involvement in regulating cell growth, apoptosis, and energy balance makes it a target of interest for researchers seeking to understand disease mechanisms and develop new therapeutic strategies.
With its high reactivity and reliability in detecting GDF15 protein expression in diverse cell types, this polyclonal antibody is an essential tool for investigating the functions and biological activities of GDF15. Its use in immunology and cancer research will provide valuable insights into the pathways and mechanisms influenced by GDF15, ultimately contributing to the development of new diagnostic and therapeutic approaches in various disease contexts.
Product Name:
GDF15 Rabbit Polyclonal Antibody
SKU:
CAB0185
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 49-308 of human GDF15 (NP_004855.2).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress.
Purification Method:
Affinity purification
Gene ID:
9518
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GDF15 Rabbit pAb (CAB0185) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
