The GDF15 Monoclonal Antibody is a specialized tool for researchers investigating the role of Growth Differentiation Factor 15 (GDF15) in various biological processes. This antibody, generated using hybridoma technology, is highly specific to GDF15 and is suitable for use in applications such as Western blot, immunofluorescence, and immunohistochemistry.GDF15 is a protein associated with diverse functions including cell growth, inflammation, and metabolism. Elevated levels of GDF15 have been linked to conditions such as cancer, cardiovascular disease, and metabolic disorders, making it a promising biomarker for disease diagnosis and prognosis.
By utilizing the GDF15 Monoclonal Antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and explore potential therapeutic interventions targeting GDF15. With its high specificity and sensitivity, the GDF15 Monoclonal Antibody is a valuable tool for advancing research in areas such as cancer biology, cardiovascular health, and metabolic disorders. Its versatility and reliability make it an indispensable asset for scientists seeking to unravel the complexities of GDF15 signaling pathways and their impact on human health.
Product Name:
GDF15 Monoclonal Antibody
SKU:
CAB22097
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human GDF15 (NP_004855.2).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress.
Purification Method:
Affinity purification
Gene ID:
9518
Clone Number:
ARC55565
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of HT-1080 cells, using GDF15 antibody (CAB22097) at1:2000 dilution.HT-1080 cells were treated by PMA/TPA (200 nM) at 37℃ for 30 minutes.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 45s.
