The GDF11 Antibody (PAC019357) is a powerful tool for researchers studying Growth Differentiation Factor 11 (GDF11), a member of the TGF-beta superfamily with roles in various biological processes. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting GDF11 protein in human samples, making it a valuable asset for Western blot applications.GDF11 is known for its regulatory functions in cell growth, development, and tissue regeneration, making it a promising target for investigations in developmental biology, aging, and cardiovascular research. With its ability to specifically bind to GDF11, this antibody enables precise detection and analysis in different cell types, facilitating in-depth studies in these areas.
The importance of GDF11 in various physiological processes and its potential implications in age-related diseases like cardiovascular issues and neurodegenerative disorders highlight the significance of this antibody for advancing our understanding of GDF11 biology. Research utilizing the GDF11 Antibody can contribute to the development of therapeutic strategies aimed at harnessing the potential of GDF11 for treating age-related conditions and promoting tissue regeneration.
Antibody Name:
GDF11 Antibody (PACO19357)
Antibody SKU:
PACO19357
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human GDF11
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lymphoma tissue using PACO19357(GDF11 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19357(GDF11 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-β superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.
Synonyms:
growth differentiation factor 11
UniProt Protein Function:
GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family.
UniProt Protein Details:
Protein type:Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 12q13.2
Cellular Component: extracellular space; intracellular membrane-bound organelle; nucleoplasm; protein complex
Biological Process: camera-type eye morphogenesis; cell development; cell maturation; growth; mesoderm development; metanephros development; negative regulation of cell proliferation; negative regulation of neuron differentiation; nervous system development; palate development; pancreas development; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development; spinal cord anterior/posterior patterning; ureteric bud development
NCBI Summary:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]
