GDF1 Antibody (PACO17978)
- SKU:
- PACO17978
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
GDF1 Antibody (PACO17978)
The GDF1 Polyclonal Antibody (PAC017978) is a valuable tool for researchers studying GDF1, a member of the transforming growth factor-beta (TGF-β) superfamily known for its role in embryonic development and tissue regeneration. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the GDF1 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for investigations in developmental biology, regenerative medicine, and cancer research.
GDF1, also known as growth differentiation factor 1, is a key signaling molecule that plays a crucial role in cell growth, differentiation, and organ development. Dysregulation of GDF1 expression has been linked to various developmental disorders, such as congenital heart defects and skeletal malformations, as well as cancer progression. Understanding the mechanisms underlying GDF1 function is essential for elucidating its impact on physiological processes and identifying potential therapeutic targets for a range of diseases.
| Antibody Name: | GDF1 Antibody (PACO17978) |
| Antibody SKU: | PACO17978 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human GDF1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO17978(GDF1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
| Background: | This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-β superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a bicistronic mRNA that also encodes the longevity assurance gene. |
| Synonyms: | Growth differentiation factor 1 |
| UniProt Protein Function: | GDF1: May mediate cell differentiation events during embryonic development. Defects in GDF1 are a cause of conotruncal heart malformations (CTHM). A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Defects in GDF1 are the cause of transposition of the great arteries dextro-looped type 3 (DTGA3). A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. The presence or absence of associated cardiac anomalies defines the clinical presentation and surgical management of patients with transposition of the great arteries. Defects in GDF1 are a cause of tetralogy of Fallot (TOF). A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19p12 Cellular Component: extracellular space Molecular Function:growth factor activity; cytokine activity; transforming growth factor beta receptor binding Biological Process: regulation of apoptosis; BMP signaling pathway; regulation of MAPKKK cascade; cell development; growth Disease: Transposition Of The Great Arteries, Dextro-looped 3; Right Atrial Isomerism; Conotruncal Heart Malformations; Tetralogy Of Fallot |
| NCBI Summary: | This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a bicistronic mRNA that also encodes the longevity assurance gene. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Mar 2014] |
| UniProt Code: | P27539 |
| NCBI GenInfo Identifier: | 116242492 |
| NCBI Gene ID: | 2657 |
| NCBI Accession: | P27539.2 |
| UniProt Secondary Accession: | P27539,O43344, |
| UniProt Related Accession: | P27539 |
| Molecular Weight: | 372 |
| NCBI Full Name: | Embryonic growth/differentiation factor 1 |
| NCBI Synonym Full Names: | growth differentiation factor 1 |
| NCBI Official Symbol: | GDF1Â Â |
| NCBI Official Synonym Symbols: | RAI; DORV; DTGA3Â Â |
| NCBI Protein Information: | embryonic growth/differentiation factor 1; GDF-1 |
| UniProt Protein Name: | Embryonic growth/differentiation factor 1 |
| Protein Family: | Embryonic growth/differentiation factor |
| UniProt Gene Name: | GDF1Â Â |
| UniProt Entry Name: | GDF1_HUMAN |
| ELISA Kits |
| Human GDF1 ELISA Kit |
| Human GDF1 (Growth Differentiation Factor 1) CLIA Kit (HUES01052) |
| Human Embryonic growth/differentiation factor 1 (GDF1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Rat GDF1 ELISA Kit
Human GDF1 ELISA Kit
Rat Growth Differentiation Factor 1 (GDF1) ELISA Kit
Mouse GDF1 / Growth Differentiation Factor 1 ELISA Kit
