The GDAP1L1 Antibody (PAC009440) is a polyclonal antibody designed for research involving GDAP1L1, a protein involved in the maintenance and function of the mitochondrial outer membrane. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunofluorescence.GDAP1L1 plays a key role in mitochondrial dynamics and function, making it a crucial target for studies in neurology, specifically in the context of neurodegenerative diseases such as Charcot-Marie-Tooth disease.
By detecting and analyzing GDAP1L1 protein levels in different cell types, researchers can gain insights into mitochondrial dysfunction and its implications for neuronal health.Understanding the role of GDAP1L1 in mitochondrial maintenance and dysfunction is essential for developing potential therapeutic interventions for neurological disorders linked to mitochondrial dysfunction. The GDAP1L1 Antibody offers a valuable tool for researchers interested in exploring the molecular mechanisms underlying these diseases and developing targeted therapies.
ganglioside-induced differentiation-associated protein 1-like 1;GDAP1L1;DKFZp761K228;dJ881L22.1;dJ995J12.1.1 ;
UniProt Protein Function:
GDAP1L1: The ganglioside GD3 synthase causes cell differentiation with neurite sprouting when transfected into the mouse neuroblastoma cell line Neuro2a. After differentiation, the expression of several genes is upregulated, including one that encodes a protein termed ganglioside-induced differentiation-associated protein 1 (Gdap1). A similar gene was found in humans, and mutations in the human gene are associated with Charcot-Marie-Tooth type 4A disease. The protein encoded by this gene is similar in sequence to the human GDAP1 protein. Several transcript variants encoding different isoforms, as well as a noncoding transcript variant, have been found for this gene. [provided by RefSeq, Feb 2012]Chromosomal Location of Human Ortholog: 20q12
UniProt Protein Details:
NCBI Summary:
The ganglioside GD3 synthase causes cell differentiation with neurite sprouting when transfected into the mouse neuroblastoma cell line Neuro2a. After differentiation, the expression of several genes is upregulated, including one that encodes a protein termed ganglioside-induced differentiation-associated protein 1 (Gdap1). A similar gene was found in humans, and mutations in the human gene are associated with Charcot-Marie-Tooth type 4A disease. The protein encoded by this gene is similar in sequence to the human GDAP1 protein. Several transcript variants encoding different isoforms, as well as a noncoding transcript variant, have been found for this gene. [provided by RefSeq, Feb 2012]
