GCSH Rabbit Polyclonal Antibody (CAB13695)
- SKU:
- CAB13695
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | GCSH Rabbit Polyclonal Antibody |
SKU: | CAB13695 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human GCSH (NP_004474.2). |
Sequence: | MALR VVRS VRAL LCTL RAVP SPAA PCPP RPWQ LGVG AVRT LRTG PALL SVRK FTEK HEWV TTEN GIGT VGIS NFAQ EALG DVVY CSLP EVGT KLNK QDEF GALE SVKA ASEL YSPL SGEV TEIN EALA ENPG LVNK SCYE DGWL IKMT LSNP SELD ELMS EEAY EKYI KSIE E |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | GCE; NKH; GCSH |
Positive Sample: | Mouse kidney,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion. |
Calculated MW: | 19kDa |
Observed MW: | 15kDa |
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.
Purification Method: | Affinity purification |
Gene ID: | 2653 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |