The GCNT2 Polyclonal Antibody (PACO09436) is an essential tool for researchers studying GCNT2, an enzyme involved in the biosynthesis of glycoproteins. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the GCNT2 protein, this antibody enables accurate detection and analysis of GCNT2 levels in various cell types, making it an indispensable tool for investigations in glycobiology and cancer research.GCNT2 plays a crucial role in the modification of glycoproteins, which are essential for cell signaling, adhesion, and immune response modulation. Dysregulation of GCNT2 has been implicated in diseases such as cancer and inflammatory disorders, making it a promising target for therapeutic interventions.
Understanding the function and regulation of GCNT2 is vital for developing novel treatments that target glycosylation pathways in disease settings.Overall, the GCNT2 Polyclonal Antibody (PACO09436) is a valuable resource for researchers seeking to dissect the role of GCNT2 in glycosylation processes and its implications in disease pathogenesis. Its high specificity and reliability make it an excellent choice for studies aiming to unravel the complex interplay between glycoproteins and disease progression.
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group);GCNT2;CCAT;GCNT2C;GCNT5;IGNT;II;MGC163396;NACGT1;NAGCT1;ULG3;bA360O19.2;bA421M1.1 ;
UniProt Protein Function:
GCNT2A: Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C. Belongs to the glycosyltransferase 14 family. 3 isoforms of the human protein are produced by alternative splicingProtein type: EC 2.4.1.150Chromosomal Location of Human Ortholog: 6p24.2Cellular Component: Golgi membrane; membrane; integral to membraneMolecular Function: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activityBiological Process: glycosaminoglycan biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of heterotypic cell-cell adhesion; multicellular organismal development; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; protein amino acid glycosylation; positive regulation of cell migrationDisease: Blood Group, I System
UniProt Protein Details:
NCBI Summary:
This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
