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GCN2 Rabbit Monoclonal Antibody (CAB2307)

SKU:
CAB2307
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:GCN2 Rabbit Monoclonal Antibody
SKU:CAB2307
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GCN2 (NP_001013725.2).
Sequence:MAGG RGAP GRGR DEPP ESYP QRQD HELQ ALEA IYGA DFQD LRPD ACGP VKEP PEIN LVLY PQGL TGEE VYVK VDLR VKCP PTYP DVVP EIEL KNAK GLSN ESVN LLKS RLEE LAKK HCGE VMIF ELAY HVQS FLSE HNKP PPKS FHEE MLER RAQE EQQR LLEA KRKE EQEQ REIL HEIQ RRKE EIKE EKKR KEMA KQER LEIA SLSN QDHT SKKD PGGH RTAA ILHG GSPD FVGN GKHR ANSS GRSR RERQ YSVC NSED SPGS CEIL YFNM GSPD QLMV HKGK CIGS DEQL GKLV YNAL
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:100 - 1:500
Synonyms:GCN2; PVOD2
Positive Sample:HeLa,293T,Mouse brain,Rat brain
Conjugate:Unconjugated
Cellular Localization:Cytosol, Cytosolic ribosome
Calculated MW:69kDa/183kDa/186kDa
Observed MW:220kDa

This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.

Purification Method:Affinity purification
Gene ID:440275
Clone Number:ARC52336
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using GCN2 Rabbit mAb (CAB2307) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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