The GCN2 Rabbit Monoclonal Antibody (CAB2307) is a valuable tool for researchers studying the GCN2 protein, a key regulator of amino acid metabolism and stress response pathways. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications.GCN2 is a critical sensor of amino acid availability in cells, playing a vital role in the integrated stress response and the regulation of protein synthesis under nutrient stress conditions. Dysregulation of GCN2 activity has been implicated in various diseases, including metabolic disorders, neurodegenerative diseases, and cancer.
By using the GCN2 Rabbit Monoclonal Antibody, researchers can effectively investigate the expression levels and localization of GCN2 in different cell types and tissues, providing valuable insights into its function and potential therapeutic applications. This antibody is a valuable tool for studies in cell biology, metabolism, and cancer research, offering high specificity and sensitivity for detecting GCN2 protein levels in various experimental settings.
Product Name:
GCN2 Rabbit Monoclonal Antibody
SKU:
CAB2307
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GCN2 (NP_001013725.2).
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.
Purification Method:
Affinity purification
Gene ID:
440275
Clone Number:
ARC52336
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using GCN2 Rabbit mAb (CAB2307) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
