GCLC Rabbit Monoclonal Antibody (CAB4499)
- SKU:
- CAB4499
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- GCL
- GCS
- GLCL
- GLCLC
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | GCLC Rabbit Monoclonal Antibody |
SKU: | CAB4499 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 538-637 of human GCLC (P48506). |
Sequence: | LNSY LENM EVDV DTRC SILN YLKL IKKR ASGE LMTV ARWM REFI ANHP DYKQ DSVI TDEM NYSL ILKC NQIA NELC ECPE LLGS AFRK VKYS GSKT DSSN |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | GCL; GCS; GLCL; GLCLC; GCLC |
Positive Sample: | HeLa,HepG2,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, glutamate-cysteine ligase complex, mitochondrion |
Calculated MW: | 73kDa |
Observed MW: | 73kDa |
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Purification Method: | Affinity purification |
Gene ID: | 2729 |
Clone Number: | ARC1065 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |