GCLC Rabbit Polyclonal Antibody (CAB1038)
- SKU:
- CAB1038
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | GCLC Rabbit Polyclonal Antibody |
SKU: | CAB1038 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-252 of human GCLC (NP_001489.1). |
Sequence: | MGLL SQGS PLSW EETK RHAD HVRR HGIL QFLH IYHA VKDR HKDV LKWG DEVE YMLV SFDH ENKK VRLV LSGE KVLE TLQE KGER TNPN HPTL WRPE YGSY MIEG TPGQ PYGG TMSE FNTV EANM RKRR KEAT SILE ENQA LCTI TSFP RLGC PGFT LPEV KPNP VEGG ASKS LFFP DEAI NKHP RFST LTRN IRHR RGEK VVIN VPIF KDKN TPSP FIET FTED DEAS RASK PDHI YMDA MGFG MGNC CLQV |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:3000 IF/ICC,1:50 - 1:200 |
Synonyms: | GCL; GCS; GLCL; GLCLC; GCLC |
Positive Sample: | HeLa,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, glutamate-cysteine ligase complex, mitochondrion |
Calculated MW: | 73kDa |
Observed MW: | 73kDa |
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Purification Method: | Affinity purification |
Gene ID: | 2729 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |